I often see patients who have trialed and failed multiple SSRIs and SNRIs, with the complaint these medications worked at first but lost efficacy over time. I will hear things such as they noticed significant improvement in their mood in the first few months, later resulting in increased anxiety and worsening depressive symptoms. Through careful
Lamotrigine, a drug originally developed to treat epilepsy, has gained significant attention in recent years for its role in managing mood disorders, particularly as a mood stabilizer and augmentation agent in major depressive disorder (MDD). While its primary mechanism of action was initially focused on controlling seizures, ongoing research has revealed that lamotrigine possesses unique